"A world-wide case-controlled observational study on the association between arboviruses and GBS"

A world-wide prospective study of INC on prognosis and biomarkers in GBS

New Online Toolkit for the Management of GBS

Based on the recently published '10-step guideline' for GBS, an online toolkit was developed in collaboration with The Global Health Network, to aid clinicians world-wide in their management of GBS. Check out the toolkit at: https://rede.tghn.org/gbs-flowchart-sample/introduction-gbs/ More >>

10 step guideline for GBS

Researchers part of the IGOS-Zika network and other scientists part of the ZikaPLAN Consortium have developed a globally applicable guideline for the diagnosis and management of Guillain–Barré syndrome(GBS) as a tool for clinicians. The paper "Diagnosis and management of Guillain-Barré syndrome in ten steps"was published in the high-impact journal ‘Nature Reviews Neurology’ on September 20, 2019


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The International Zika virus related Guillain-Barré syndrome Outcome Study (IGOS-Zika) is a worldwide prospective case-controlled study that aims to determine the association between Guillain-Barré syndrome (GBS) and Zika virus (ZIKV), and the clinical phenotype and disease course of arboviral-related GBS.

In 2015 the epidemic of ZIKV and the subsequent rise in incidence of GBS cases caused worldwide concern. Currently, the association between ZIKV and GBS, the clinical phenotype and pathogenesis are unclear. With IGOS-Zika we aim to close these gaps in knowledge.  

IGOS-Zika has a minimum follow-up period of 6 months. All patients with GBS, or variants of GBS (including the Miller Fisher syndrome), within 2 weeks of onset of weakness can be included, irrespective of gender, age, severity and treatment. Clinical data and blood samples are obtained prospectively at several follow-up visits. For every patient, 2 hospital based controls, matched for age and gender, are included in the study, of whom a short questionnaire and blood samples are collected. Data is obtained using questionnares and a web-based data entry system. The study is conducted according to the criteria of Good Clinical Practice, certifying the anonymous and highly secured storage of data.